Berberine-d6 (chloride)

Berberine-d6 (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

Product Specifications

Product Name Alternative

Natural Yellow 18-d6 (chloride)

UNSPSC

12352005

Target

Antibiotic; Autophagy; Bacterial; Endogenous Metabolite; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS) ; Topoisomerase

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])([2H])OC1=C(OC([2H])([2H])[2H])C2=C[N+]3=C(C4=CC5=C(C=C4CC3)OCO5)C=C2C=C1.[Cl-]

Molecular Formula

C20H12D6ClNO4

Molecular Weight

377.85

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Cai Y, et al. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 2014 Jan;68 (1) :53-62.