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(R) -Avanafil

(R) -Avanafil ((R) -TA1790) is a selective PDE5 inhibitor (IC50: 5.2 nM) . (R) -Avanafil can be used for research of erectile dysfunction[1].

Product Specifications

CAS Number

1638497-26-3

Product Name Alternative

(R) -TA1790

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/r-avanafil.html

Solubility

10 mM in DMSO

Smiles

COC1=C(Cl)C=C(CNC2=C(C(NCC3=NC=CC=N3)=O)C=NC(N4[C@@H](CO)CCC4)=N2)C=C1

Molecular Formula

C23H26ClN7O3

Molecular Weight

483.95

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Sakamoto T, et al. The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor. Bioorg Med Chem Lett. 2014 Dec 1;24 (23) :5460-5.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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