(R) -Avanafil
(R) -Avanafil ((R) -TA1790) is a selective PDE5 inhibitor (IC50: 5.2 nM) . (R) -Avanafil can be used for research of erectile dysfunction[1].
Product Specifications
CAS Number
[1638497-26-3]
Product Name Alternative
(R) -TA1790
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/r-avanafil.html
Solubility
10 mM in DMSO
Smiles
COC1=C(Cl)C=C(CNC2=C(C(NCC3=NC=CC=N3)=O)C=NC(N4[C@@H](CO)CCC4)=N2)C=C1
Molecular Formula
C23H26ClN7O3
Molecular Weight
483.95
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Sakamoto T, et al. The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor. Bioorg Med Chem Lett. 2014 Dec 1;24 (23) :5460-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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