PRE-084

PRE-084 is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].

Product Specifications

CAS Number

[138847-85-5]

UNSPSC

12352005

Hazard Statement

H302

Target

Akt; NO Synthase; Sigma Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pre-084.html

Solubility

10 mM in DMSO

Smiles

O=C(OCCN1CCOCC1)C2(CCCCC2)C3=CC=CC=C3

Molecular Formula

C19H27NO3

Molecular Weight

317.42

Precautions

P264-P270-P330-P501

References & Citations

[1]Marrazzo A, et al. Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport. 2005 Aug 1;16 (11) :1223-6. |[2]Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-32. |[3]Gao QJ, et al. Sigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats. Chin Med J (Engl) . 2018 Mar 5;131 (5) :539-543. |[4]Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259 (2) :543-50.