AM-8553
AM-8553 is a MDM2/p53 inhibitor (KD: 0.4 nM for MDM2) . AM-8553 has anti-tumor activity[1]
Product Specifications
CAS Number
1352064-70-0
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/am-8553.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C[C@]1(C)C(N([C@@H](CC)[C@@H](O)C)[C@H](C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC(Cl)=C3)C1)=O
Molecular Formula
C25H29Cl2NO4
Molecular Weight
478.41
References & Citations
[1]Bernard D, et al. AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development. J Med Chem. 2012 Jun 14;55 (11) :4934-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS951506-01 0.02 mg (E-Coli)
Recombinant Mouse Alpha-centractin (Actr1a)
Sign In for Pricing
View Details MBS951506-02 0.02 mg (Yeast)
Recombinant Mouse Alpha-centractin (Actr1a)
Sign In for Pricing
View Details