Sacubitrilat-d4
Sacubitrilat-d4 is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor[1].
Product Specifications
Product Name Alternative
Desethyl Sacubitril-d4; LBQ-657-d4
UNSPSC
12352005
Hazard Statement
H336, H372
Target
Isotope-Labeled Compounds; Neprilysin
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC([C@H](C)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC(C=C1)=CC=C1C2=CC=CC=C2)=O
Molecular Formula
C22H21D4NO5
Molecular Weight
387.46
Precautions
H336, H372
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci Rep. 2016 Jun 15;6:27909.|[3]Langenickel TH, et al. Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization. Eur J Clin Pharmacol. 2016 Aug;72 (8) :917-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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