Sacubitrilat-d4

Sacubitrilat-d4 is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor[1].

Product Specifications

Product Name Alternative

Desethyl Sacubitril-d4; LBQ-657-d4

UNSPSC

12352005

Hazard Statement

H336, H372

Target

Isotope-Labeled Compounds; Neprilysin

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC([C@H](C)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC(C=C1)=CC=C1C2=CC=CC=C2)=O

Molecular Formula

C22H21D4NO5

Molecular Weight

387.46

Precautions

H336, H372

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci Rep. 2016 Jun 15;6:27909.|[3]Langenickel TH, et al. Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization. Eur J Clin Pharmacol. 2016 Aug;72 (8) :917-24.