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Folinic acid-d4 (calcium hydrate)

Folinic acid-d4-1 (Leucovorin-d4-1) calcium hydrate is deuterated labeled Folinic acid. Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease Methotrexate-induced toxicity.

Product Specifications

Product Name Alternative

Leucovorin-d4 (calcium hydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antifolate; Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

91.69

Solubility

DMSO : 250 mg/mL (ultrasonic; warming)

Smiles

O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(NC([2H])([2H])C2([2H])N(C=O)C3=C(NC(N)=NC3=O)NC2[2H])C=C1)=O.[F,Cl,Br,I].O.[Ca+2]

Molecular Formula

C20H17D4CaN7O7.xH2O

Precautions

H302, H315, H319, H335

References & Citations

[1]Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397 (2) : p. 221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92 (12) :1438-44.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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