Folinic acid (calcium hydrate)
Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along with Methotrexate as a rescue agent to decrease Methotrexate-induced toxicity[1].
Product Specifications
CAS Number
1097832-14-8
Product Name Alternative
Leucovorin (calcium hydrate)
UNSPSC
12352005
Target
Antifolate; Endogenous Metabolite
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/folinic-acid-calcium-hydrate.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O.[Ca].O
Molecular Formula
C20H25CaN7O8
Molecular Weight
531.53
References & Citations
[1]Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397 (2) : p. 221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92 (12) :1438-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
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