Metoprolol (fumarate)

Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3].

Product Specifications

CAS Number

[80274-67-5]

Product Name Alternative

CGP 2175C; Lopressor OROS

UNSPSC

12352005

Target

Adrenergic Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/metoprolol-fumarate.html

Solubility

10 mM in DMSO

Smiles

OC(CNC(C)C)COC1=CC=C(CCOC)C=C1.O=C(O)/C=C/C(O)=O.OC(CNC(C)C)COC2=CC=C(CCOC)C=C2

Molecular Formula

C34H54N2O10

Molecular Weight

650.80

References & Citations

[1]Ulleryd MA, et al. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783.|[2]Wang D, et al. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1;547 (2) :195-201.|[3]Hajatbeigi B, et al. Cytotoxicity of Metoprolol on Leukemic Cells in Vitro. IJBC 2018; 10 (4) : 124-129.|[4]Su Q, et al. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring;18 (2) :161-5.