(1S,2R) -Tranylcypromine (hydrochloride)

(1S,2R) -Tranylcypromine ((1S,2R) -SKF 385) hydrochloride is a potent antidepressant agent. (1S,2R) -Tranylcypromine hydrochloride can inhibits MAO and LSD1[1][2].

Product Specifications

CAS Number

[4548-34-9]

Product Name Alternative

(1S,2R) -SKF 385 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Histone Demethylase; Monoamine Oxidase

Type

Reference compound

Related Pathways

Epigenetics; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1s-2r-tranylcypromine-hydrochloride.html

Concentration

5.89 mM * 1 mL in isopropanol

Solubility

10 mM in DMSO

Smiles

N[C@H]1C[C@@H]1C2=CC=CC=C2.[H]Cl

Molecular Formula

C9H12ClN

Molecular Weight

169.65

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]TetsuyaEzawa, et al. Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1S,2R) -tranylcypromine. Tetrahedron: Asymmetry. 15 December 2017;28 (12) :1690-1699.|[2]Valente S, et al. Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies. ACS Med Chem Lett. 2014 Dec 8;6 (2) :173-7.