Penciclovir-d4

Penciclovir-d4 is the deuterium labeled Penciclovir. Penciclovir is reported to be potent against HSV types 1 and 2 with IC50 of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively[1][2].

Product Specifications

CAS Number

[1020719-72-5]

Product Name Alternative

BRL 39123-d4; VSA 671-d4

UNSPSC

12352005

Target

HSV; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Field of Research

Infection

Purity

97.0

Solubility

10 mM in DMSO|DMSO : 25mg/mL (ultrasonic) |H2O : 2mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OCC(CO)C([2H])([2H])C([2H])([2H])N1C2=C(C(N=C(N2)N)=O)N=C1

Molecular Formula

C10H11D4N5O3

Molecular Weight

257.28

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Piret J, et al. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management. Antimicrob Agents Chemother. 2011 Feb;55 (2) :459-72.|[3]Xiong Z, et al. Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living micewith mutant herpes simplex virus type 1 thymidine kinase PET reporter gene. J Nucl Med. 2006 Jan;47 (1) :130-9.