Acyclovir monophosphate

Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity[1][2].

Product Specifications

CAS Number

[66341-16-0]

UNSPSC

12352005

Target

Antibiotic; HSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/acyclovir-monophosphate.html

Solubility

10 mM in DMSO

Smiles

O=C1N=C(NC2=C1N=CN2COCCOP(O)(O)=O)N

Molecular Formula

C8H12N5O6P

Molecular Weight

305.18

References & Citations

[1]Yao J, et al. Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. J Control Release. 2013 Sep 28;170 (3) :414-20.|[2]Elion GB, et al. Mechanism of action and selectivity of acyclovir. Am J Med. 1982 Jul 20;73 (1A) :7-13.