Racecadotril-d5

Racecadotril-d5 is the deuterium labeled Racecadotril. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent[1].

Product Specifications

CAS Number

[1246815-11-1]

Product Name Alternative

Acetorphan-d5

UNSPSC

12352005

Hazard Statement

H302-H400

Target

Isotope-Labeled Compounds; Neprilysin

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Solubility

10 mM in DMSO

Smiles

[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1COC(CNC(C(CSC(C)=O)CC2=CC=CC=C2)=O)=O

Molecular Formula

C21H18D5NO4S

Molecular Weight

390.51

Precautions

P264-P270-P273-P330-P391-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Marion Eberlin, et al. A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor Racecadotril. Front Pharmacol. 2012 May 30;3:93.|[3]David W Griggs, et al. Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. J Pharmacol Exp Ther. 2016 May;357 (2) :423-31.