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Terbinafine-d3 (hydrochloride)

Terbinafine-d3 hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

Product Specifications

CAS Number

1310012-15-7

Product Name Alternative

TDT 067-d3 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Bacterial; Fungal; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Field of Research

Infection

Purity

99.87

Solubility

DMSO : 10 mg/mL (ultrasonic; warming) |Ethanol : 30 mg/mL (ultrasonic; warming)

Smiles

CC(C)(C)C#C/C=C/CN(C([2H])([2H])[2H])CC1=CC=CC2=C1C=CC=C2.Cl

Molecular Formula

C21H23D3ClN

Molecular Weight

330.91

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69 (8) :679-82.|[3]Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14 (2) :104-8.|[4]Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-8.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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