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Terbinafine (lactate)

Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

335276-86-3

Product Name Alternative

TDT 067 (lactate)

UNSPSC

12352005

Target

Antibiotic; Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/terbinafine-lactate.html

Solubility

10 mM in DMSO

Smiles

CC(O)C(O)=O.CN(C/C=C/C#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1

Molecular Formula

C24H31NO3

Molecular Weight

381.51

References & Citations

[1]Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-8.|[2]Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14 (2) :104-8.|[3]Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69 (8) :679-82.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Frequently Asked Questions

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