Loxapine (hydrochloride)
Loxapine hydrochloride is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent[1][4].
Product Specifications
CAS Number
54810-23-0
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/loxapine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1.[H]Cl
Molecular Formula
C18H19Cl2N3O
Molecular Weight
364.27
References & Citations
[1]Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21 (1) :29-35.|[2]Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15 (1) :23-30. |[3]Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12 (4) :277-85.|[4]Keating GM. Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia. CNS Drugs. 2013 Jun;27 (6) :479-89.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D1 Receptor; D2 Receptor; D4 Receptor; α-1 microglobulin
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