(rel) -Oxaliplatin

(rel) -Oxaliplatin is a DNA synthesis inhibitor. (rel) -Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. (rel) -Oxaliplatin can be used for cancer research[1][2][3].

Product Specifications

CAS Number

[63121-00-6]

UNSPSC

12352211

Hazard Statement

H315-H317-H319-H335-H351

Target

Apoptosis; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rel-oxaliplatin.html

Solubility

10 mM in DMSO

Smiles

O=C1[O-][Pt+2]2([O-]C1=O)[NH2][C@@](CCCC3)([H])[C@]3([H])[NH2]2

Molecular Formula

C8H14N2O4Pt

Molecular Weight

397.29

Precautions

P261-P264-P271-P272-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Woynarowski JM, et, al. Oxaliplatin-induced damage of cellular DNA. Mol Pharmacol. 2000 Nov;58 (5) :920-7.|[2]Wang Z, et, al. Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth. Expert Opin Investig Drugs. 2009 Nov;18 (11) :1595-604.|[3]Pendyala L, et, al. In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin. Cancer Res. 1993 Dec 15;53 (24) :5970-6.