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Esomeprazole-d6 (sodium)

Esomeprazole-d6 sodium is the deuterium labeled Esomeprazole. Esomeprazole ((S) -Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

Product Specifications

CAS Number

922731-04-2

Product Name Alternative

(S) -Omeprazole-d6 (sodium) ; (-) -Omeprazole-d6 (sodium)

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Proton Pump

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Solubility

10 mM in DMSO

Smiles

CC(C(OC([2H])([2H])[2H])=C(C=N1)C)=C1C[S@@](C(NC2=C3)=NC2=CC=C3OC([2H])([2H])[2H])=O.[Na]

Molecular Formula

C17H13D6N3NaO3S

Molecular Weight

374.44

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17 (3) :439-46.|[3]Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.|[4]Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59 (14) :1333-9.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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