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Esomeprazole-d3

Esomeprazole-d3 is deuterium labeled Esomeprazole. Esomeprazole ((S) -Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

Product Specifications

Product Name Alternative

(S) -Omeprazole-d3; (-) -Omeprazole-d3

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Proton Pump

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology; Inflammation/Immunology

Purity

99.71

Solubility

10 mM in DMSO

Smiles

O=[S@](C1=NC2=C([2H])C([2H])=C(OC)C([2H])=C2N1)CC3=NC=C(C)C(OC)=C3C

Molecular Formula

C17H16D3N3O3S

Molecular Weight

348.43

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.|[3]Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59 (14) :1333-9.|[4]Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17 (3) :439-46.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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