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Bepridil

Bepridil ((±) -Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2].

Product Specifications

CAS Number

64706-54-3

Product Name Alternative

(±) -Bepridil; Org 5730

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Calcium Channel; SARS-CoV; Sodium Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bepridil.html

Solubility

10 mM in DMSO

Smiles

CC(COCC(CN(C1=CC=CC=C1)CC2=CC=CC=C2)N3CCCC3)C

Molecular Formula

C24H34N2O

Molecular Weight

366.54

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Yatani A, et al. Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther. 1986 Apr;237 (1) :9-17.|[2]Vatansever EC, et al. Bepridil is potent against SARS-CoV-2 in vitro. Proc Natl Acad Sci U S A. 2021 Mar 9;118 (10) :e2012201118.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Frequently Asked Questions

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