5'-Methylthioadenosine-d3

5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine[1]. 5'-Methylthioadenosine (5'- (Methylthio) -5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4].

Product Specifications

CAS Number

[174838-38-1]

Product Name Alternative

5'- (Methylthio) -5'-deoxyadenosine-d3; 5'-S-Methyl-5'-thioadenosine-d3

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Endogenous Metabolite; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Purity

99.90

Solubility

DMF : 2.5mg/mL (ultrasonic) |DMSO : 50mg/mL (ultrasonic) |H2O : 1mg/mL (ultrasonic)

Smiles

NC1=C2N([C@]3([H])O[C@@H]([C@H]([C@H]3O)O)CSC([2H])([2H])[2H])C=NC2=NC=N1

Molecular Formula

C11H12D3N5O3S

Molecular Weight

300.35

Precautions

H302

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37 (5) :1366-1373.2018;78 (15) :4386-4395.|[3]Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.|[4]Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res.|[5]Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.