5'-Methylthioadenosine-13C6

5'-Methylthioadenosine-13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'- (Methylthio) -5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

Product Specifications

CAS Number

[2421187-73-5]

Product Name Alternative

5'- (Methylthio) -5'-deoxyadenosine-13C6; 5'-Deoxy-5'- (methylthio) adenosine-13C6; 5'-S-Methyl-5'-thioadenosine-13C6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-methylthioadenosine-13c6.html

Purity

98.45

Solubility

10 mM in DMSO

Smiles

O[13C@H]1[13C@@H](O)[13C@@]([H])(O[13C@@H]1[13CH2]S[13CH3])N2C=NC3=C2N=CN=C3N

Molecular Formula

C5 13C6H15N5O3S

Molecular Weight

303.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37 (5) :1366-1373.|[2]Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.|[3]Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78 (15) :4386-4395.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[5]Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.