Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Lefamulin

Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia[1].

Product Specifications

CAS Number

1061337-51-6

Product Name Alternative

BC-3781

UNSPSC

12352211

Hazard Statement

H315, H319, H320

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lefamulin.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H]1[C@]23[C@](C(CC3)=O)([H])[C@]([C@@H](C[C@](C)([C@H]1O)C=C)OC(CS[C@H]4[C@@H](C[C@@H](CC4)N)O)=O)([C@@H](CC2)C)C

Molecular Formula

C28H45NO5S

Molecular Weight

507.73

Precautions

H315, H319, H320

References & Citations

[1]Veve MP, et al. Lefamulin: Review of a Promising Novel Pleuromutilin Antibiotic. Pharmacotherapy. 2018 Sep;38 (9) :935-946. doi: 10.1002/phar.2166. Epub 2018 Aug 20.|[2]Susanne Paukner, et al. Antimicrob Agents Chemother. 2018 Apr 26;62 (5) :e02380-17. |[3]Ken B Waites, et al. In Vitro Activities of Lefamulin and Other Antimicrobial Agents against Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China. Antimicrob Agents Chemother. 2017 Jan 24;61 (2) :e02008-16. |[4]Michael Hafner, et al. Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse model. PLoS One. 2021 Sep 29;16 (9) : e0237659. https://pubmed.ncbi.nlm.nih.gov/34587166/|[5]Wolfgang W Wicha, et al. Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumonia. J Antimicrob Chemother. 2019 Apr 1;74 (Suppl 3) :iii11-iii18.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Rabbit CPT1A (Carnitine Palmitoyltransferase 1A, Liver) ELISA Kit
ELK9796-01 48 Tests

Rabbit CPT1A (Carnitine Palmitoyltransferase 1A, Liver) ELISA Kit

Sign In for Pricing
View Details
Rabbit CPT1A (Carnitine Palmitoyltransferase 1A, Liver) ELISA Kit
ELK9796-02 96 Tests

Rabbit CPT1A (Carnitine Palmitoyltransferase 1A, Liver) ELISA Kit

Sign In for Pricing
View Details
Rabbit CPT1A (Carnitine Palmitoyltransferase 1A, Liver) ELISA Kit
ELK9796-03 5x 96 Tests

Rabbit CPT1A (Carnitine Palmitoyltransferase 1A, Liver) ELISA Kit

Sign In for Pricing
View Details
Goat Claudin-20 (CLDN20) ELISA Kit
MBS7216289-01 48 Well

Goat Claudin-20 (CLDN20) ELISA Kit

Sign In for Pricing
View Details
Goat Claudin-20 (CLDN20) ELISA Kit
MBS7216289-02 96 Well

Goat Claudin-20 (CLDN20) ELISA Kit

Sign In for Pricing
View Details
Goat Claudin-20 (CLDN20) ELISA Kit
MBS7216289-03 5x 96 Well

Goat Claudin-20 (CLDN20) ELISA Kit

Sign In for Pricing
View Details