Sarecycline

Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne[1][2][3][4][5][6].

Product Specifications

CAS Number

[1035654-66-0]

Product Name Alternative

P-005672

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sarecycline.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@](C(O)=C(C(C1=C(C=C2)O)=O)[C@](CC1=C2CN(C)OC)([H])C3)(C(C(C(N)=O)=C4O)=O)[C@]3([H])[C@@H]4N(C)C

Molecular Formula

C24H29N3O8

Molecular Weight

487.50

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Zhanel G, et al. Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris. Antimicrob Agents Chemother. 2018 Dec 21;63 (1) :e01297-18.|[2]Moore AY, et al. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019 Sep;14 (14) :1235-1242.|[3]Batool Z, et al. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc Natl Acad Sci U S A. 2020 Aug 25;117 (34) :20530-20537. |[4]Butler MS, et al. Antibiotics in the clinical pipeline in 2013. J Antibiot (Tokyo) . 2013 Oct;66 (10) :571-91.|[5]Moore AY, et al. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019 Sep;14 (14) :1235-1242. |[6]Bunick CG, et al. Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation. Antibiotics (Basel) . 2021 Apr 15;10 (4) :439.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Tetracycline

Citation 01

Clin Exp Pharmacol Physiol. 2023 Jul;50 (7) :604-609.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0323822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0071823.|Pharmaceutics. 2021 Dec 5;13 (12) :2085.