Sonidegib-d4
Product Specifications
UNSPSC Description
Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].
Target Antigen
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
CC1=C(C=CC=C1C2=CC=C(C=C2)OC(F)(F)F)C(NC3=CC=C(N=C3)N4C([2H])([C@@H](O[C@@H](C4([2H])[2H])C)C)[2H])=O
Molecular Weight
489.52
References & Citations
[1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Curated Selection
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