Etifoxine-d5
Etifoxine-d5 is the deuterium labeled Etifoxine. Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents[1][2][3].
Product Specifications
CAS Number
1346598-10-4
UNSPSC
12352005
Target
GABA Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
[2H]C1=C(C2(C)OC(NCC)=NC3=CC=C(Cl)C=C32)C([2H])=C(C([2H])=C1[2H])[2H]
Molecular Formula
C17H12D5ClN2O
Molecular Weight
305.81
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA (A) receptors in rodents. Neurosci Res. 2002 Oct;44 (2) :167-72.|[3]Alain Hamon, et al. The modulatory effects of the anxiolytic etifoxine on GABA (A) receptors are mediated by the beta subunit. Neuropharmacology. 2003 Sep;45 (3) :293-303.|[4]Marc Verleye, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21 (6) :457-70.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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