Zoptarelin doxorubicin

Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1].

Product Specifications

CAS Number

[139570-93-7]

Product Name Alternative

AEZS-108; AN-152

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

GnRH Receptor; Peptide-Drug Conjugates (PDCs)

Type

Peptides

Related Pathways

Antibody-drug Conjugate/ADC Related; GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zoptarelin-doxorubicin.html

Solubility

H2O

Smiles

OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N)=C1C[C@](O)(C4)C(COC(CCCC(NCCCC[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(NCC(N)=O)=O)=O)=O)=O)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H]7NC(CC7)=O)=O)CC8=CN=CN8)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)CC%11=CC=C(C=C%11)O)=O)=O)=O)=O

Molecular Formula

C91H117N19O26

Molecular Weight

1893.01

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jaszberenyi M, et al. Inhibition of U-87 MG glioblastoma by AN-152 (AEZS-108), a targeted cytotoxic analog of luteinizing hormone-releasing hormone. Oncotarget. 2013 Mar;4 (3) :422-32.