Terodiline (hydrochloride)

Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1].

Product Specifications

CAS Number

[7082-21-5]

UNSPSC

12352005

Hazard Statement

H302, H319, H400

Target

Calcium Channel; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/terodiline-hydrochloride.html

Purity

99.78

Solubility

DMSO : 40 mg/mL (ultrasonic; warming)

Smiles

CC(NC(C)(C)C)CC(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl

Molecular Formula

C20H28ClN

Molecular Weight

317.90

Precautions

H302, H319, H400

References & Citations

[1]Noronha-Blob L, et al. (+/-) -Terodiline: an M1-selective muscarinic receptor antagonist. In vivo effects at muscarinic receptors mediating urinary bladder contraction, mydriasis and salivary secretion. Eur J Pharmacol. 1991 Aug 29;201 (2-3) :135-42.