C-ABL-IN-6
C-ABL-IN-6 (compound A6) is a c-ABL inhibitor with IC50 value of 16.6 nM. c-ABL-IN-6 displays higher neuroprotective effects against SH-SY5Y cell death induced by MPP+. c-ABL-IN-6 can be used for the research of neurodegenerative disorder[1].
Product Specifications
UNSPSC
12352005
Target
Bcr-Abl
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/c-abl-in-6.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C(NC2=CC(C(F)(F)F)=CC(C3=CN(C)N=C3)=C2)=O)C=C1NC(C4=CN=C5C(C=CN5)=C4)=O
Molecular Formula
C27H21F3N6O2
Molecular Weight
518.49
References & Citations
[1]Yang Z, et al. Discovery of conformationally constrained c-Abl inhibitors with potential neuroprotective effects against Parkinson's disease. Bioorg Med Chem. 2023 Dec 15;96:117532.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSH031672 50 µg
Recombinant Human Iduronate 2-Sulfatase/IDS Protein (His Tag)
Sign In for Pricing
View Details 
BNUB1283-100 1x 100 µL
VEGI (Vascular Endothelial Growth Inhibitor) (VEGI/1283), 0.2mg/mL
Sign In for Pricing
View Details