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C-ABL-IN-6

C-ABL-IN-6 (compound A6) is a c-ABL inhibitor with IC50 value of 16.6 nM. c-ABL-IN-6 displays higher neuroprotective effects against SH-SY5Y cell death induced by MPP+. c-ABL-IN-6 can be used for the research of neurodegenerative disorder[1].

Product Specifications

UNSPSC

12352005

Target

Bcr-Abl

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/c-abl-in-6.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(C(NC2=CC(C(F)(F)F)=CC(C3=CN(C)N=C3)=C2)=O)C=C1NC(C4=CN=C5C(C=CN5)=C4)=O

Molecular Formula

C27H21F3N6O2

Molecular Weight

518.49

References & Citations

[1]Yang Z, et al. Discovery of conformationally constrained c-Abl inhibitors with potential neuroprotective effects against Parkinson's disease. Bioorg Med Chem. 2023 Dec 15;96:117532.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Abl

Frequently Asked Questions

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