JAK3/BTK-IN-7
JAK3/BTK-IN-7 (XL-12) is a JAK3/BTK inhibitor with IC50 values of 2 nM and 14 nM, respectively. JAK3/BTK-IN-7 has anti-inflammatory activity and can be used in the study of rheumatoid arthritis[1].
Product Specifications
CAS Number
2844387-16-0
UNSPSC
12352005
Target
Btk; JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak3-btk-in-7.html
Solubility
10 mM in DMSO
Smiles
NC1=C2C(C3=C4C(OCO4)=C(C=C3)NC(C5=CC=C(C=C5)N(C)C)=O)=NN([C@H]6CN(CCC6)C(C=C)=O)C2=NC=N1
Molecular Formula
C29H30N8O4
Molecular Weight
554.60
References & Citations
[1]Liang T, et al. Discovery of Novel Dual Bruton’s Tyrosine Kinase (BTK) and Janus Kinase 3 (JAK3) Inhibitors as A Promising Strategy for Rheumatoid Arthritis[J]. Bioorganic & Medicinal Chemistry, 2023: 117354.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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