ATAG 4531

ATAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader. Red: MTH1 aTAG inhibitor (HY-134725), Blue: CRBN ligand (HY-126457), Black: linker (HY-108374) [1].

Product Specifications

CAS Number

[2412985-00-1]

Product Name Alternative

CFT-4531

UNSPSC

12352005

Target

DNA/RNA Synthesis; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atag-4531.html

Purity

99.1

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(F)C=C(C2=CC3=C(NC4=CC=CC=C4)C(C(NC5CC5)=O)=CN=C3C=C2F)C=C1)NCCCCN6N=NC(COC7=CC=CC(C(N8C9C(NC(CC9)=O)=O)=O)=C7C8=O)=C6

Molecular Formula

C46H39F2N9O7

Molecular Weight

867.85

References & Citations

[1]Veits G K, et al. Development of an AchillesTAG degradation system and its application to control CAR-T activity [J]. Current Research in Chemical Biology, 2021, 1: 100010.