DHODH-IN-24
DHODH-IN-24 (compound 16) is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 91 nM[1].
Product Specifications
CAS Number
418775-30-1
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhodh-in-24.html
Solubility
10 mM in DMSO
Smiles
CN(CCN(C)/N=C/C1=CC=CC2=C1C=CC=C2)/N=C/C3=CC=CC4=C3C=CC=C4
Molecular Formula
C26H26N4
Molecular Weight
394.51
References & Citations
[1]William T Higgins, et al. Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods. J Chem Inf Model. 2024 Jan 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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