JE-133
JE-133 is an optically active isochromane-2H-chromene conjugate. JE-133 exhibits antioxidant and anti-inflammatory activities. JE-133 is a neuroprotective agent that effectively inhibits neuronal oxidative damage associated with PI3K/Akt and MAPK signaling pathways. JE-133 can also inhibit lipopolysaccharide (LPS) -induced neuroinflammation by regulating JAK/STAT and Nrf2 signaling pathways[1][2].
Product Specifications
CAS Number
2579171-69-8
UNSPSC
12352005
Target
Akt; p38 MAPK; PI3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/je-133.html
Solubility
10 mM in DMSO
Smiles
CCOC([C@@H]1C([C@H]2C3=CC(O)=C(O)C=C3C[C@H](O2)C)=CC4=CC(OC)=CC=C4O1)=O
Molecular Formula
C23H24O7
Molecular Weight
412.43
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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