AB-452
AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model[1].
Product Specifications
CAS Number
2226178-35-2
UNSPSC
12352005
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ab-452.html
Solubility
10 mM in DMSO
Smiles
CC([C@H]1N2C(C3=NC(OC)=C(OCCCOC)C=C3C1)=CC(C(C(O)=O)=C2)=O)C
Molecular Formula
C21H26N2O6
Molecular Weight
402.44
References & Citations
[1]Dimitar Gotchev, et al. Structure-Activity Relationships and Discovery of (S) -6-Isopropyl-2-methoxy-3- (3-methoxypropoxy) -10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer. J. Med. Chem. January 8, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
589208 96 Tests
Diacylglycerol Kinase Alpha (DGKa) BioAssayTM ELISA Kit (Human)
Sign In for Pricing
View Details