PAN endonuclease-IN-1

PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target[1].

Product Specifications

CAS Number

[2378640-67-4]

UNSPSC

12352005

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pan-endonuclease-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C(NC(C1=C(C(F)(F)F)C=C(C2=NN=NN2)C=C1)=C3)=C(O)C3=O)O

Molecular Formula

C14H8F3N5O4

Molecular Weight

367.24

References & Citations

[1]Alysia J Kohlbrand, et al. Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry. 2024 Jan 8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

225111-01 50 µL

PKR (Interferon-induced, double-stranded RNA-Activated Protein Kinase, Eukaryotic Translation Initiation Factor 2-alpha Kinase 2, eIF-2A Protein Kinase 2, Interferon-inducible RNA-Dependent Protein Kinase, P1/eIF-2A Protein Kinase, Protein Kinase RNA-Activated, PKR, Tyrosine-Protein Kinase EIF2AK2, p68 Kinase, PKR, PRKR, EIF2AK2) discontinued

Ask

View Details

225111-02 100 µL

PKR (Interferon-induced, double-stranded RNA-Activated Protein Kinase, Eukaryotic Translation Initiation Factor 2-alpha Kinase 2, eIF-2A Protein Kinase 2, Interferon-inducible RNA-Dependent Protein Kinase, P1/eIF-2A Protein Kinase, Protein Kinase RNA-Activated, PKR, Tyrosine-Protein Kinase EIF2AK2, p68 Kinase, PKR, PRKR, EIF2AK2) discontinued

Ask

View Details

GTR15112450 1 Vial

Lentiviral human SPATA31D4 shRNA (UAS) - Lentiviral human SPATA31D4 shRNA (UAS, GFP) plasmid

Ask

View Details

E28PE4417 100 µL

FCGR2A (CD32) (6T4) Mouse Monoclonal antibody

Ask

View Details

ELI-18088b 96 Tests

Bovine RG9MTD3 ELISA KIT

Ask

View Details

FAB9697CL1 0.1 mL

Rabbit Monoclonal GFR alpha-like Antibody (2345C) [CoraFluor 1]

Ask

View Details