HDAC8-IN-6
HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC50 of 5.1 μM. HDAC8-IN-6 shows cytotoxicity[1].
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac8-in-6.html
Solubility
10 mM in DMSO
Smiles
C[N+]1=CC=C(NC(CC(N2CC3=C(C=CC=C3)C2)=O)=O)C(C#C)=C1.[I-]
Molecular Formula
C19H18IN3O2
Molecular Weight
447.27
References & Citations
[1]Keeley AB, et al. Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors. J Med Chem. 2024 Jan 11;67 (1) :572-585.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC4; HDAC8
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