PCSK9-IN-24
PCSK9-IN-24 (Compound OY3) is a compound that targets PCSK9. PCSK9-IN-24 reduces PCSK9 levels and increases LDL uptake and may be used in atherosclerosis research[1].
Product Specifications
CAS Number
2974496-96-1
UNSPSC
12352005
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-in-24.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=C(C=C1OCCCCN(C3=C/4C=C(C=C3)Br)C(C4=C/C5=CC(OC)=C(C(Br)=C5)O)=O)C(CC(NC6=NC=CS6)=O)(C)NCC2
Molecular Formula
C36H36Br2N4O6S
Molecular Weight
812.57
References & Citations
[1]Ouyang Z, et al. Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds. J Med Chem. 2024 Jan 11;67 (1) :433-449.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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