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Autophagy/REV-ERB-IN-1

Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of autophagy and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a CC50 value of 2.3 μM on BTB-474 cells.

Product Specifications

UNSPSC

12352005

Target

Autophagy; REV-ERB

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/autophagy-rev-erb-in-1.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(C2(NCC3=CC=C(F)C(CC4CCNCC4)=C3)CCCC2)C=C1

Molecular Formula

C24H30F2N2

Molecular Weight

384.51

References & Citations

[1]Martina Palomba, et al. Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy. J Med Chem. 2024, 67, 1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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