Glucosylceramide synthase-IN-4
Product Specifications
UNSPSC Description
Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity[1].
Target Antigen
Glucosylceramide Synthase (GCS)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glucosylceramide-synthase-in-4.html
Solubility
10 mM in DMSO
Smiles
CC1=NN=C(C2=CC=C(C=C2)C3=C4C(N(CC4=CC(F)=C3F)[C@H](C(F)(F)F)C(C)(O)C)=O)O1
Molecular Weight
467.39
References & Citations
[1]H. Marie Loughran, et al. Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections. ACS Med. Chem. Lett. 2024, 15, 1, 123-131.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163131/Glucosylceramide-synthase-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163131/
Clinical Information
No Development Reported
CAS Number
2776965-41-2
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