Glucosylceramide synthase-IN-4

Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity[1].

Product Specifications

CAS Number

[2776965-41-2]

UNSPSC

12352005

Target

Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glucosylceramide-synthase-in-4.html

Solubility

10 mM in DMSO

Smiles

CC1=NN=C(C2=CC=C(C=C2)C3=C4C(N(CC4=CC(F)=C3F)[C@H](C(F)(F)F)C(C)(O)C)=O)O1

Molecular Formula

C22H18F5N3O3

Molecular Weight

467.39

References & Citations

[1]H. Marie Loughran, et al. Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections. ACS Med. Chem. Lett. 2024, 15, 1, 123-131.