AChE-IN-52
AChE-IN-52 (compound A6) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-52 shows antitumor efficacy, especially against breast cancer MCF-7 cells. AChE-IN-52 significantly disrupts the amino acid metabolism and inhibits migration of MCF-7. AChE-IN-52 plays anticancer role by regulating Best1 and HIST1H2BJ[1].
Product Specifications
CAS Number
2214210-63-4
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ache-in-52.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CSC(C2=CC=C(OCC3=CC=CC=C3)C=C2)=N1)NCCN4CCCCC4
Molecular Formula
C24H27N3O2S
Molecular Weight
421.56
References & Citations
[1]Shi X, et al. Identification of a 2-phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells. Chem Biol Drug Des. 2023 Nov 27:e14402.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
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