BHEPN
BHEPN is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) . BHEPN has inhibition of VEGFR-2 with an IC50 value of 0.320 μM. BHEPN also exhibits remarkable cytotoxic effects against HepG2 and MCF-7 cancer cell lines, with IC50 values of 0.19 μM and 1.18 μM, respectively. BHEPN can be used for anticancer research[1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bhepn.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(/C(C)=N/NC(C2=CC=C(Br)C=C2)=O)=C1)C3=CN=CC=C3
Molecular Formula
C21H17BrN4O2
Molecular Weight
437.29
References & Citations
[1]Eissa IH, et al. Exploring the anticancer properties of a new nicotinamide analogue: Investigations into in silico analysis, antiproliferative effects, selectivity, VEGFR-2 inhibition, apoptosis induction, and migration suppression. Pathol Res Pract. 2023 Dec;252:154924.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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