Anti-inflammatory agent 67

Anti-inflammatory agent 67 (compound 7a) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib (HY-16726), and has anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 67 has IC50s of 10.4 μM and 50 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 67 binding to different isoforms of carbonic anhydrase are 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), and 13.3 nM (CA XII) [1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Carbonic Anhydrase; COX

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-67.html

Solubility

10 mM in DMSO

Smiles

O=S(OC(C=C1)=NN(C2=CC=C(S(=O)(N)=O)C=C2)C1=O)(C)=O

Molecular Formula

C11H11N3O6S2

Molecular Weight

345.35

References & Citations

[1]Badawi WA, et al. Identification of new 4- (6-oxopyridazin-1-yl) benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2201407.