NNRT-IN-2

NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC50 of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics[1].

Product Specifications

CAS Number

2999794-78-2

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nnrt-in-2.html

Solubility

10 mM in DMSO

Smiles

CN1C(NN=C1CN2C=CC(C(F)(F)F)=C(C2=O)OC3=C4C=CN=CC4=CC=C3)=O

Molecular Formula

C19H14F3N5O3

Molecular Weight

417.34

References & Citations

[1]Zhao LM, et al. Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility. Acta Pharm Sin B. 2023 Dec;13 (12) :4906-4917.