HR488B
HR488B is an efficient HDAC1 inhibitor. HR488B specifically suppressed the growth of CRC cells by inducing cell cycle G0/G1 arrest and apoptosis. HR488B causes mitochondrial dysfunction, reactive oxygen species (ROS) generation, and DNA damage accumulation[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hr488b.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)N(C(CCCCCC(NO)=O)=O)CC2=NC(C3=CC=CC=C3Cl)=CS2
Molecular Formula
C24H26ClN3O4S
Molecular Weight
488.00
References & Citations
[1]Namin Duan, et al. Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth. Cell Death Dis. 2023, 4, 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1
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