HR488B

HR488B is an efficient HDAC1 inhibitor. HR488B specifically suppressed the growth of CRC cells by inducing cell cycle G0/G1 arrest and apoptosis. HR488B causes mitochondrial dysfunction, reactive oxygen species (ROS) generation, and DNA damage accumulation[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; HDAC; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hr488b.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1)N(C(CCCCCC(NO)=O)=O)CC2=NC(C3=CC=CC=C3Cl)=CS2

Molecular Formula

C24H26ClN3O4S

Molecular Weight

488.00

References & Citations

[1]Namin Duan, et al. Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth. Cell Death Dis. 2023, 4, 12.