Anticancer agent 175
Anticancer agent 175 (complex 1) ia a near-infrared (NIR) luminescent theranostic complex. Anticancer agent 175 induces ROS accumulation, mitochondrial damage, disruption of Bax/Bcl-2 equilibrium, and tumor cell apoptosis in HepG2 cell line[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-175.html
Solubility
10 mM in DMSO
Smiles
CC1=C2C3=CC=CC=C3[Ir]45([N]6=C7C=C(F)C(F)=CC7=NC(C)=C6C8=CC=CC=C84)([N]9=C%10C=CC=CC%10=C(C(NCCCCCCNC([C@@](C)(CC[C@@]%11(CC[C@@]%12(C%13=CC([C@@]%14([C@]%15(CC[C@@H](C([C@@]%15(CC[C@@]%12%14C)[H])(C)C)O)C)[H])=O)C)C)C[C@]%11%13[H])=O)=O)C=C9C%16=CC=CC=[N]%165)[N]2=C%17C=C(F)C(F)=CC%17=N1.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Molecular Formula
C81H86F10IrN8O4P-
Molecular Weight
1648.78
References & Citations
[1]Wang L, et al. A glycyrrhetinic acid-iridium (III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability. Eur J Med Chem. Published online November 25, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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