Tubulin/NRP1-IN-1
Product Specifications
UNSPSC Description
Tubulin/NRP1-IN-1 (compound TN-2) is a dual inhibitor of Tubulin and NRP1 with IC50s of 0.71 and 0.85 μM, respectively. Tubulin/NRP1-IN-1 significantly inhibits the viability of prostate tumor cell lines and induces apoptosis[1].
Target Antigen
Apoptosis; Complement System; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-nrp1-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C(C=C1OC)/C=C\C2=CC(NC(CCC(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=C(C=C2)OC)OC
Molecular Weight
571.62
References & Citations
[1]Zheng L, et al. Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation. J Med Chem. 2023 Dec 14;66(23):16187-16200.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163062/Tubulin-NRP1-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163062/
Clinical Information
No Development Reported
CAS Number
2983719-82-8
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