Tubulin/NRP1-IN-1

Tubulin/NRP1-IN-1 (compound TN-2) is a dual inhibitor of Tubulin and NRP1 with IC50s of 0.71 and 0.85 μM, respectively. Tubulin/NRP1-IN-1 significantly inhibits the viability of prostate tumor cell lines and induces apoptosis[1].

Product Specifications

CAS Number

[2983719-82-8]

UNSPSC

12352005

Target

Apoptosis; Complement System; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-nrp1-in-1.html

Solubility

10 mM in DMSO

Smiles

COC1=C(C=C(C=C1OC)/C=C\C2=CC(NC(CCC(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=C(C=C2)OC)OC

Molecular Formula

C28H37N5O8

Molecular Weight

571.62

References & Citations

[1]Zheng L, et al. Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation. J Med Chem. 2023 Dec 14;66 (23) :16187-16200.