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Antitumor photosensitizer-5

Antitumor photosensitizer-5 (Ru2) is a photosensitizer which effectively target tumor mitochondria with an IC50 of 0.3 μM for phototoxicity to A549 cells. Under 460 nm light irradiation, antitumor photosensitizer-5 induces the generation of reactive oxygen species and NADH depletion, causes mitochondrial damage and activation of caspase-3, inducing apoptosis and suppressing cell migration. Antitumor photosensitizer-5 has the potential to prevent the growth of malignant tumors, therefore, shows the potential to be applied to photodynamic therapy[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-photosensitizer-5.html

Solubility

10 mM in DMSO

Smiles

O=C(CCCCC1SCC2NC(NC21)=O)NC3=CC=C(C(N4)=NC5=C4C(C=CC=[N]67)=C6C8=C5C=CC=[N]8[Ru+2]9%107([N]%11=C%12C(C=CC%13=C%12[N]%10=CC=C%13)=CC=C%11)[N]%14=CC=CC%15=C%14C%16=[N]9C=CC=C%16C=C%15)C=C3.[F-][P+5]([F-])([F-])([F-])([F-])[F-].[F-][P+5]([F-])([F-])([F-])([F-])[F-]

Molecular Formula

C53H43F12N11O2P2RuS

Molecular Weight

1289.04

References & Citations

[1]Guoqiang Shao, et al. Biotin-conjugated Ru (II) complexes with AIE characteristics as mitochondria-targeted photosensitizers for enhancing photodynamic therapy by disrupting cellular redox balance. European Journal of Medicinal Chemistry. 2023, Volume 264, 115985.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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