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FABP4-IN-3

FABP4-IN-3 (compound C3) is a highly selective FABP4 inhibitor (FABP4 Ki = 25 ± 3a nM, FABP3 Ki = 15.03 μM) which exhibits a 601-fold selectivity over FABP3. FABP4-IN-3 also shows metabolic stability and potent cellular anti-inflammatory activity, making it promising to get involved in the research of metabolic disease, cardiac dysfunction and inflammation-related disease[1].

Product Specifications

UNSPSC

12352005

Target

FABP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fabp4-in-3.html

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=CC(NC2=CC=CC(Cl)=C2C3=CC=CC=C3)=C1C(O)=O

Molecular Formula

C20H16ClNO2

Molecular Weight

337.80

References & Citations

[1]Yechun Xu, et al. Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3. European Journal of Medicinal Chemistry. 2023, Journal Pre-proof.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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